pycea.datasets.yang22

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pycea.datasets.yang22#

pycea.datasets.yang22(tumors='3435_NT_T1', cache_dir='~/.treedata/datasets')#

Single-cell lineage tracing from KP mouse model [YJN+22].

In this study, CRISPR Cas9-based single-cell lineage tracing was performed in the KP autochthonous mouse model of non-small-cell lung cancer. Tumors were initiated with Cre recombinase and allowed to grow for approximately 4-6 months at which point mice were sacrificed and tumors harvested. After purifying cancer cells by fluorescent markers, cells were profiled with the 10X chromium platform.

Parameters:

  • tumors (str | list[str] | None (default: '3435_NT_T1')) – The set of tumors to load. Default is “3435_NT_T1”.

  • cache_dir (PathLike | str (default: '~/.treedata/datasets')) – The directory where the datasets are cached. Default is ~/.treedata/datasets.

Return type:

TreeData

Returns:

TreeData object.

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